个人主页
金梅林
  • 专业技术职务:教授
  • 部     门:动科动医学院
  • 联系电话:13871316142
  • 电子邮箱:jinmeilin@mail.hzau.edu.cn
  • 研究方向:人兽共患传染病流行病学、致病机制、新型疫苗与分子诊断制剂

个人简介 收起

金梅林,女,湖北武汉人。华中农业大学教授、博士生导师,预防兽医学系系主任,农业部兽用诊断制剂创制重点实验室主任,农业微生物学国家重点实验室动物病原分室主任。国务院政府特殊津贴、湖北省新世纪高层次人才支持计划、“3551光谷人才计划”获得者。北京大学理学学士、华中农业大学农学博士。兼任中国畜牧兽医学会传染病学分会副理事长;湖北省免疫学会常务理事;湖北省生物工程学会常务理事。科技部高等级病原微生物生物安全审查委员会委员,农业部动物防疫专家委员会委员,湖北省突发公共卫生事件咨询专家。 长期坚持在科研、教学一线,致力于科学研究、人才培养和平台建设。多年来她以产业发展中的重大问题为导向,重点从事人兽共患传染病流行病学、致病机制、新型疫苗与分子诊断制剂研究并取得丰硕成果,多项成果填补了国内外空白。先后获授权发明专利49项;获得3项国家科技进步二等奖(两项为第一完成人,一项第二完成人),获其他省部级科技奖励8项;获第四届中国侨界贡献奖。2012、2016年两次获湖北高校十大优秀科技成果转化奖。2016年获何梁何利科学与技术进步奖。获2011年获第七届大北农科技一等奖。研发畜禽新型疫苗和诊断试剂30余种;以第一完成人获得新兽药注册证书7项,参与相关研究获新兽药注册证书14项。2012、2016年两次获湖北高校十大优秀科技成果转化奖。主编和参编著作7部。

代表性论文收起

  • 1. Insights into Human Astrocyte Response to H5N1 Infection by Microarray Analysis VIRUSES-BASEL 2015.07
  • 2. 14-Deoxy-11,12-dehydroandrographolide exerts anti-influenza A virus activity and inhibits replication of H5N1 virus by restraining nuclear export of viral ribonucleoprotein complexes ANTIVIRAL RESEARCH 2015.06
  • 3. Molecular detection of hepatitis E virus in sheep from southern Xinjiang, China VIRUS GENES 2015.06
  • 4. Investigation of Pathogenesis of H1N1 Influenza Virus and Swine Streptococcus suis Serotype 2 Co-Infection in Pigs by Microarray Analysis PLoS One 2015.05
  • 5. Efficient strategy for constructing duck enteritis virus-based live attenuated vaccine against homologous and heterologous H5N1 avian influenza virus and duck enteritis virus infection VETERINARY RESEARCH 2015.05
  • 6. CHD3 facilitates vRNP nuclear export by interacting with NES1 of influenza A virus NS2 CELLULAR AND MOLECULAR LIFE SCIENCES 2015.03
  • 7. A novel pro-inflammatory protein of Streptococcus suis 2 induces the Toll-like receptor 2-dependent expression of pro-inflammatory cytokines in RAW 264.7 macrophages via activation of ERK1/2 pathway FRONTIERS IN MICROBIOLOGY 2015.03
  • 8. Porcine interferon-induced protein with tetratricopeptide repeats 3, poIFIT3, inhibits swine influenza virus replication and potentiates IFN-beta production DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2015.03
  • 9. Identification and characterisation a surface-associated arginine peptidase in Streptococcus suis serotype 2 Elsevier GmbH, v 170, p 168-176, January 1, 2015 2015.01
  • 10. Identification and characterisation a surface-associated arginine peptidase in Streptococcus suis serotype 2 MICROBIOLOGICAL RESEARCH 2015.01
  • 11. Efficient Strategy to Generate a Vectored Duck Enteritis Virus Delivering Envelope of Duck Tembusu Virus VIRUSES-BASEL 2014.07
  • 12. PB2-588I Enhances 2009 H1N1 Pandemic Influenza Virus Virulence by Increasing Viral Replication and Exacerbating PB2 Inhibition of Beta Interferon Expression JOURNAL OF VIROLOGY 2014.03
  • 13. Antimicrobial Susceptibility, Tetracycline and Erythromycin Resistance Genes, and Multilocus Sequence Typing of Streptococcus suis Isolates from Diseased Pigs in China JOURNAL OF VETERINARY MEDICAL SCIENCE 2014.01
  • 14. Identification and characterisation a surface-associated arginine peptidase in Streptococcus suis serotype 2 Microbiological Research 2014.01
  • 15. Fluoroquinolone-Resistant Haemophilus parasuis Isolates Exhibit More Putative Virulence Factors than Their Susceptible Counterparts JOURNAL OF CLINICAL MICROBIOLOGY 2013.09
  • 16. The 2009 pandemic (H1N1) viruses isolated from pigs show enhanced pathogenicity in mice VETERINARY RESEARCH 2013.07
  • 17. Molecular characterisation of resistance to fluoroquinolones in Haemophilus parasuis isolated from China INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 2013.07
  • 18. Glycoprotein C plays a role in the adsorption of duck enteritis virus to chicken embryo fibroblasts cells and in infectivity VIRUS RESEARCH 2013.07
  • 19. Insights into the increasing virulence of the swine-origin pandemic H1N1/2009 influenza virus SCIENTIFIC REPORTS 2013.05
  • 20. Characterization of Streptococcus suis serotype 2 isolates from China VETERINARY MICROBIOLOGY 2013.01
  • 21. HP0197 Contributes to CPS Synthesis and the Virulence of Streptococcus suis via CcpA PLOS ONE 2013.01
  • 22. Complete Genome Sequence of a Novel H4N1 Influenza Virus Isolated from a Pig in Central China JOURNAL OF VIROLOGY 2012.01
  • 23. Identification of Human Host Proteins Contributing to H5N1 Influenza Virus Propagation by Membrane Proteomics JOURNAL OF PROTEOME RESEARCH 2012.01
  • 24. Complete Genome Sequence of an H10N5 Avian Influenza Virus Isolated from Pigs in Central China JOURNAL OF VIROLOGY 2012.01
  • 25. A DNA vaccine encoding the FMDV capsid precursor polypeptide P1 and the enhancing effect of bovine herpesvirus 1 VP22 protein as molecular adjuvant ACTA VIROLOGICA 2012.01
  • 26. The new temperature-sensitive mutation PA-F35S for developing recombinant avian live attenuated H5N1 influenza vaccine VIROLOGY JOURNAL 2012.01
  • 27. Genetic Characterization of a Novel Recombinant H5N2 Avian Influenza Virus Isolated from Chickens in Tibet JOURNAL OF VIROLOGY 2012.01
  • 28. Haemophilus parasuis Encodes Two Functional Cytolethal Distending Toxins: CdtC Contains an Atypical Cholesterol Recognition/Interaction Region PLOS ONE 2012.01
  • 29. Analysis of cellular proteome alterations in porcine alveolar macrophage cells infected with 2009 (H1N1) and classical swine H1N1 influenza viruses JOURNAL OF PROTEOMICS 2012.01
  • 30. Complete Genome Sequence of a Novel Natural Recombinant H5N5 Influenza Virus from Ducks in Central China JOURNAL OF VIROLOGY 2012.01
  • 31. The antigenic property of the H5N1 avian influenza viruses isolated in central China VIROLOGY JOURNAL 2012.01
  • 32. Pandemic (H1N1) 2009 Virus in Swine Herds, People's Republic of China EMERGING INFECTIOUS DISEASES 2011.01
  • 33. Large-Scale Identification of Bacteria-Host Crosstalk by Affinity Chromatography: Capturing the Interactions of Streptococcus suis Proteins with Host Cells JOURNAL OF PROTEOME RESEARCH 2011.01
  • 34. Comparative Genomics Study of Multi-Drug-Resistance Mechanisms in the Antibiotic-Resistant Streptococcus suis R61 Strain PLOS ONE 2011.01
  • 35. Effects of the C-Terminal Truncation in NS1 Protein of the 2009 Pandemic H1N1 Influenza Virus on Host Gene Expression PLOS ONE 2011.01
  • 36. Transcription analysis on response of swine lung to H1N1 swine influenza virus BMC GENOMICS 2011.01
  • 37. Complete Genome Sequence of Streptococcus suis Serotype 14 Strain JS14 JOURNAL OF BACTERIOLOGY 2011.01
  • 38. Complete Genome Sequence of Streptococcus suis Serotype 3 Strain ST3 JOURNAL OF BACTERIOLOGY 2011.01
  • 39. IgA1 protease contributes to the virulence of Streptococcus suis VETERINARY MICROBIOLOGY 2011.01
  • 40. Effect of human activated NRAS on replication of delNS1 H5N1 influenza virus in MDCK cells VIROLOGY JOURNAL 2011.01
  • 41. Emergence of novel reassortant H3N2 influenza viruses among ducks in China ARCHIVES OF VIROLOGY 2011.01
  • 42. Effect on Virulence and Pathogenicity of H5N1 Influenza A Virus through Truncations of NS1 eIF4GI Binding Domain JOURNAL OF INFECTIOUS DISEASES 2010.01
  • 43. Proteomics Analysis of Differential Expression of Chicken Brain Tissue Proteins in Response to the Neurovirulent H5N1 Avian Influenza Virus Infection JOURNAL OF PROTEOME RESEARCH 2010.01
  • 44. The Special Neuraminidase Stalk-Motif Responsible for Increased Virulence and Pathogenesis of H5N1 Influenza A Virus PLOS ONE 2010.01
  • 45. Response of swine spleen to Streptococcus suis infection revealed by transcription analysis BMC GENOMICS 2010.01
  • 46. Identification and characterization of IgA1 protease from Streptococcus suis VETERINARY MICROBIOLOGY 2010.01
  • 47. Identification of a cell wall-associated subtilisin-like serine protease involved in the pathogenesis of Streptococcus suis serotype 2 MICROBIAL PATHOGENESIS 2010.01
  • 48. Evaluation of the protective efficacy of a newly identified immunogenic protein, HP0272, of Streptococcus suis FEMS MICROBIOLOGY LETTERS 2010.01
  • 49. Quantum-dots-based fluoroimmunoassay for the rapid and sensitive detection of avian influenza virus subtype H5N1 Luminescence 2010.01

指导研究生优秀论文 收起

  • 1. 猪链球菌毒力相关蛋白HP0197的结构生物学研究以及喹诺酮耐药相关基因突变研究 校优论文 袁增智 2013
  • 2. 猪链球菌全基因组测序及比较基因组学研究 省优论文 胡攀 2012
  • 3. 猪链球菌与宿主细胞的相互作用以及毒力相关蛋白HP0197的功能研究 校优论文 陈博 2012
  • 4. 猪链球菌全基因组测序及比较基因组学研究 校优论文 胡攀 2011

教学情况 收起

  • 1. 细胞生物学B
  • 2. 动物传染病学A
  • 3. 禽病学
  • 4. 细胞生物学C
  • 5. 动物传染病学

科研项目 收起

  • 1. 科前合作鸭坦布苏病毒病灭活疫苗联合开发协议 2017.02
  • 2. 猪链球菌转录因子SiteR、SxvR和SipB调控致病机制的研究 2017.01
  • 3. 技术开发咨询服务合同 2016.12
  • 4. 科前合作副猪嗜血杆菌病二联亚单位疫苗联合开发协议书 2016.11
  • 5. 动物流感病毒与宿主蛋白互作机制研究 2016.07
  • 6. 动物流感病毒遗传变异与致病机理研究 2016.07
  • 7. 农业部兽用诊断制剂创制重点实验室条件建设项目 2015.04
  • 8. 红斑丹毒丝菌毒力相关因子的发掘及其影响黏附、侵入的分子机理研究 2015.01
  • 9. 猪链球菌病和副猪嗜血杆菌病二联亚单位疫苗技术开发 2014.01
  • 10. 鸿翔鸭场疫病综合免疫防控 2014.01
  • 11. 武汉市春江禽业疫病防控 2014.01
  • 12. 藏猪样品中猪瘟和猪肺炎支原体病原微生物检测 2013.01
  • 13. H5亚型重组禽流感病毒反应器培养工艺四方协议 2012.01
  • 14. 病原菌的免疫应答与免疫逃避机制(参加) 2012.01
  • 15. 流感病毒感染过程中宿主细胞相关因子的发掘及功能研究 2011.01
  • 16. 禽流感快速检测技术的创制及产业化研究 2011.01
  • 17. 畜禽重要细菌病基因工程疫苗的研究和开发 2011.01
  • 18. 中牧合作猪流感H1N1灭活疫苗联合开发及技术转让 2010.07
  • 19. 中博合作流感病毒H1N1亚型灭活疫苗 2009.12
  • 20. 猪2型链球菌新型保护性抗原与宿主细胞蛋白相互作用的研究 2009.01
  • 21. 传代细胞源禽流感疫苗研究
  • 22. 猪链球菌灭活疫苗(马链球菌兽疫亚种+猪链球菌2型,7型)的研究及产业化
  • 23. 猪链球菌病原谱流行规律及耐药性研究
  • 24. 猪链球菌病防控技术研究与示范

专利成果 收起

社会服务 收起

招收研究生专业 收起

  • 1. 兽医
  • 2. 预防兽医学

其他 收起

在《Journal of Infectious Diseases》、《Emerging Infectious Diseases》、《Journal of Proteomics Research》、《Molecular Immunology》、《Cell Research》、《Vet Microbiol》、 《Journal of Clinical Microbiology》、《Journal of Bacteriology》、《Vaccine》等国际国内权威期刊发表科研论发表学术论文224篇,以第一作者和通讯作者发表研究论文126篇,其中SCI收录论文84篇;在重要病原感染与免疫机制研究领域获得一系列重大发现,相关研究于2014、2015年被Elsevier学术论文索引数据库评选为具世界影响力的中国高被引学者。