个人主页
肖少波
  • 专业技术职务:教授
  • 部     门:动科动医学院
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  • 研究方向:动物病毒;天然免疫;抗体工程;新型疫苗;诊断试剂

个人简介 收起

肖少波,1969年出生,博士,华中农业大学二级岗教授、博士生导师,国家杰出青年基金获得者、教育部“长江学者”特聘教授、湖北省自然科学基金创新研究群体学术带头人。先后入选国家农业科研杰出人才、国家中青年科技创新领军人才、国家百千万人才工程、教育部新世纪优秀人才、武汉市黄鹤科技英才等人才计划,荣获“国家有突出贡献中青年专家”等荣誉称号,享受国务院政府特殊津贴。兼任中国免疫学会兽医免疫学专业委员会委员、湖北省微生物学会畜牧兽医微生物学专业委员会主任,《病毒学报》、《中国动物传染病学报》等杂志编委。 主要开展猪繁殖与呼吸综合征病毒、猪肠道冠状病毒等重要动物病毒的病原学与流行病学、病毒与宿主免疫系统的相互作用、新型疫苗与诊断技术研究。先后承担国家自然科学基金重大项目、国家杰出青年基金、973计划、863计划、国家科技支撑计划、教育部科学技术研究重大项目等科研课题,在Journal of Virology (JVI)、Journal of Biological Chemistry (JBC)、Journal of Proteome Research (JPR) 等国际期刊上发表SCI论文90余篇,申报/获得国家发明专利15项。

代表性论文收起

  • 1. Porcine Deltacoronavirus in Mainland China EMERGING INFECTIOUS DISEASES 2015.12
  • 2. Suppression of porcine reproductive and respiratory syndrome virus proliferation by glycyrrhizin ANTIVIRAL RESEARCH 2015.07
  • 3. Porcine reproductive and respiratory syndrome virus infection activates NOD2-RIP2 signal pathway in MARC-145 cells VIROLOGY 2014.07
  • 4. Porcine Reproductive and Respiratory Syndrome Virus Induces IL-1 ss Production Depending on TLR4/MyD88 Pathway and NLRP3 Inflammasome in Primary Porcine Alveolar Macrophages MEDIATORS OF INFLAMMATION?? 2014.06
  • 5. Label-Free Quantitative Phosphoproteomic Analysis Reveals Differentially Regulated Proteins and Pathway in PRRSV-Infected Pulmonary Alveolar Macrophages JOURNAL OF PROTEOME RESEARCH 2014.04
  • 6. MiR-125b Reduces Porcine Reproductive and Respiratory Syndrome Virus Replication by Negatively Regulating the NF-kappa B Pathway PLOS ONE 2013.03
  • 7. Porcine reproductive and respiratory syndrome virus infection activates IL-10 production through NF-kappa B and p38 MAPK pathways in porcine alveolar macrophages DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2013.03
  • 8. Enhanced immunogenicity induced by an alphavirus replicon-based pseudotyped baculovirus vaccine against porcine reproductive and respiratory syndrome virus JOURNAL OF VIROLOGICAL METHODS 2013.03
  • 9. Pathogenesis of nonsuppurative encephalitis caused by highly pathogenic Porcine reproductive and respiratory syndrome virus JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION?? 2012.01
  • 10. Induction of autophagy enhances porcine reproductive and respiratory syndrome virus replication VIRUS RESEARCH 2012.01
  • 11. Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-kappa B activation VIROLOGY JOURNAL 2012.01
  • 12. Comparative Genomics of Mycoplasma: Analysis of Conserved Essential Genes and Diversity of the Pan-Genome PLOS ONE?? 2012.01
  • 13. Complete Genome Sequence of Porcine Reproductive and Respiratory Syndrome Virus Isolated from Piglet Stool Samples JOURNAL OF VIROLOGY 2012.01
  • 14. Foot-and-Mouth Disease Virus 3C Protease Cleaves NEMO To Impair Innate Immune Signaling JOURNAL OF VIROLOGY 2012.01
  • 15. Foot-and-mouth disease virus (FMDV) leader proteinase negatively regulates the porcine interferon-lambda 1 pathway MOLECULAR IMMUNOLOGY 2012.01
  • 16. miR-365, a Novel Negative Regulator of Interleukin-6 Gene Expression, Is Cooperatively Regulated by Sp1 and NF-kappa B JOURNAL OF BIOLOGICAL CHEMISTRY 2011.01
  • 17. The Leader Proteinase of Foot-and-Mouth Disease Virus Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase JOURNAL OF VIROLOGY 2011.01
  • 18. Antiviral activity of type I and type III interferons against porcine reproductive and respiratory syndrome virus (PRRSV) ANTIVIRAL RESEARCH 2011.01
  • 19. Epidemiology and Evolutionary Characteristics of the Porcine Reproductive and Respiratory Syndrome Virus in China between 2006 and 2010 JOURNAL OF CLINICAL MICROBIOLOGY 2011.01
  • 20. Understanding Streptococcus suis serotype 2 infection in pigs through a transcriptional approach BMC GENOMICS 2011.01
  • 21. Complete Genome Sequence of Mycoplasma hyopneumoniae Strain 168 JOURNAL OF BACTERIOLOGY 2011.01
  • 22. Molecular cloning of the porcine RANTES promoter: Functional characterization of dsDNA/dsRNA response elements in PK-15 cells DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2011.01
  • 23. Complete coding sequences and phylogenetic analysis of porcine bocavirus JOURNAL OF GENERAL VIROLOGY 2011.01
  • 24. The genomic diversity of Chinese porcine reproductive and respiratory syndrome virus isolates from 1996 to 2009 VETERINARY MICROBIOLOGY 2011.01
  • 25. Porcine reproductive and respiratory syndrome virus (PRRSV) infection activates chemokine RANTES in MARC-145 cells MOLECULAR IMMUNOLOGY 2011.01
  • 26. Activation of NF-kappa B by nucleocapsid protein of the porcine reproductive and respiratory syndrome virus VIRUS GENES 2011.01
  • 27. miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-κB Journal of Biological Chemistry 2011.01
  • 28. Antitumor effects of a recombinant pseudotype baculovirus expressing Apoptin in vitro and in vivo INTERNATIONAL JOURNAL OF CANCER 2010.01
  • 29. Complete Genome Sequence of Mycoplasma hyorhinis Strain HUB-1 JOURNAL OF BACTERIOLOGY 2010.01
  • 30. Molecular cloning and functional characterization of porcine stimulator of interferon genes (STING) DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2010.01
  • 31. Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2010.01

指导研究生优秀论文 收起

  • 1. PRRSV感染激活RANTES产生的信号通路研究 校优论文 王艳伟 2011
  • 2. 猪新型细小病毒PHoV和PBoV诊断方法的建立、分子流行病学调查及基因组序列分析 校优论文 曾松林 2011

教学情况 收起

  • 1. 动物传染病学B
  • 2. 动物病毒学#
  • 3. 病毒学实验
  • 4. 动物传染病学B ﹟
  • 5. 病毒学
  • 6. 动物病毒学

科研项目 收起

  • 1. 31730095猪δ冠状病毒辅助蛋白拮抗I型干扰素的机制及其对致病性的影响 2018.01
  • 2. 猪δ冠状病毒灭活疫苗(CHN-HN-2014株)联合开发协议书 2017.09
  • 3. 猪圆环病毒2型、副猪嗜血杆菌二联亚单位疫苗 2017.07
  • 4. 技术开发咨询服务合同 2016.12
  • 5. 农业部农业科研杰出人才及其创新团队 2016.01
  • 6. 创新人才推进计划中青年科技创新领军人才 2016.01
  • 7. 武汉市黄鹤英才计划(科技领域) 2015.01
  • 8. 武汉市黄鹤英才计划(科技领域) 2015.01
  • 9. 宿主抗猪繁殖与呼吸综合征病毒感染的保护性免疫机制 2015.01
  • 10. 抗仔猪腹泻卵黄抗体蛋白联合开发协议 2014.01
  • 11. 猪繁殖与呼吸综合征病毒调控炎症反应的分子机制 2014.01
  • 12. 动物病毒与宿主免疫系统的相互作用研究及新型疫苗创制 2014.01
  • 13. 猪繁殖与呼吸综合征病毒调控炎症反应的分子机制01 2014.01
  • 14. 猪繁殖与呼吸综合征病毒感染激活IL-1β的分子机制及其生物学意义 2013.01
  • 15. 动物病毒与宿主免疫系统的相互作用 2013.01
  • 16. 动物传染病学 2013.01
  • 17. 猪肺炎支原体全基因组ORFs的克隆、表达及诊断标识的挖掘 2012.01
  • 18. 猪繁殖与呼吸综合征病毒感染激活IL-10的分子机制研究 2009.01

专利成果 收起

社会服务 收起

招收研究生专业 收起

  • 1. 兽医
  • 2. 预防兽医学

其他 收起